Endocrine Abstracts

Background and Aims: Obesity is a major risk factor for type 2 diabetes (T2D). Remission of diabetes can be achieved by dietary weight loss although the underlying molecular mechanism(s) are unknown. These beneficial effects could be related to decreasing hepatic fat delivery to the pancreas and eventually restoring β-cell function. We hypothesised that hepatic de novo lipogenesis (DNL) is the primary driver of pancreas “lipotoxicity” and the pr...

Objective: To evaluate the gastric bypass effect in type 2 diabetic patients with morbid obesity, on the following terms: diabetes evolution, 10 years estimated cardiovascular risk and quality of lifeMethods: Cohort study with intrasubject measures (before–after) in a sample of patients with morbid obesity and type 2 diabetes who underwent gastric bypass. Demographic characteristics, anthropometric parameters, cardiovascular risk factors and surgica...